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It Is All About Team Execution in In Vivo Studies

lab at meadowhawk biolabs in San Francisco, CA

In Vivo work conducted at a CRO can be described as magic.

We can request a study today and Meadowhawk can dose tomorrow? Meadowhawk CAN add a tissue to the collection happening right now? How is it possible? How is it done? Let’s draw back the curtain and see how an In Vivo study team executes a study.

At Meadowhawk, teamwork is at the heart of our culture. It makes the magic happen. Whether that is working side by side in the vivarium to dose 100 IV mice, across the hall with our analytical team, or with our clients to interpret data. Our teams are committed to supporting both colleagues and clients. Meadowhawk’s goal is to become an extension of our client’s team.

Behind every good magic trick is an integrated plan for execution.

Our In Vivo teams work together to get this plan together. A study team is made up of a Study Director, Scientist, and Research Associates. Each individual brings a unique perspective and set of skills but with a common purpose – to execute each study efficiently, accurately, and with animal welfare as top priority. Study Directors work together with the Sponsor to generate a study protocol – a document to capture all the details to ensure accurate execution. Research Associates and Scientists use this protocol to plan and set up for study execution.

In a culture that promotes participation and ownership, all levels are involved in study planning discussions. All are empowered to review study protocols during planning phases and provide feedback regarding ease/plan of execution, conflicts with IACUC guidelines, or feasibility of formulation work. This is where the details for dose material needs, animal availability, blood volume limits, sample volume requirements for analysis are discussed with our analytical teams, our animal vendors, our clients. Each minor detail influences another. The volume needed for analysis dictates the number and size of animals required for study execution, which dictates the availability of the animals for study and the amount and availability of dose material needed for dosing, both of which dictates when the study can be scheduled. This all happens behind the scenes, the study is executed, a report is issued and Meadowhawk can do it all within days of request, Magic? No, teamwork.

Danielle Pessolano

Director, In Vivo Services

Danielle has extensive experience in the preclinical CRO industry. Her responsibilities have ranged from Study Director roles to Manager of In Vivo study teams. Prior to working at Charles River Laboratories on both East and West coasts, she worked at the University of Massachusetts Medical School. In each of Danielle’s roles, she has focused on process improvement, procedure refinement, and operational efficiency. Danielle is passionate about building partnerships with clients and providing exceptional customer service. She earned her BS in Biology from Framingham State University.

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