How AAALAC Accredited Rodent Vivariums Can Advance R&D Programs
Critical PK and PK/PD Experiments for Early-Stage Drug Development
Assessing PK/ADME Options
In order to advance drug R&D, accurate and fast experimental results are key to rapidly and efficiently advancing candidate therapeutics to development, in particular for small start-ups and virtual companies.
Three common types of PK related experiments often play critical roles in different stages
- Quick PK studies to reveal pharmacokinetic behavior and bioavailability of drug candidates in both systemic circulation and in target organs.
- Metabolism related study (particularly in excretion to gain insights on drug candidate’s metabolism mechanism).
- Dose range finding (DRF) study to determine the appropriate dose range before the candidate progresses to the preclinical stage.
Accurate and fast experimental results are key to rapidly and efficiently advancing candidate therapeutics to development...
Seamless Collaboration for Rapid Results
From Meadowhawk Biolabs’ inception, our In Vivo and bioanalytical teams have been working “shoulder to shoulder”, acting as one team for fast delivery of your results. Common strains of rodents (CD-1, C57bl/6, Sprague Dawley, and Wistar-Han) are readily available in our facilities for quick study start. A client dedicated study director will serve as the single point of contact, from study design, process monitor, and data delivery, to ensure study quality. Our experienced team can dose discrete or cassetted compounds, collect biofluids and tissues and transfer samples to our on-site analytical teams for immediate sample analysis. Upon client request, Meadowhawk can purchase non-standard, commercially available rodent strains for late stage PK/PD related studies.
Rapid PK and Metabolism Studies in 5 Days
Our teams are highly proficient in administering common dose routes (IV, PO, IP, IM, SC) as well as collection of biofluids and targeted tissues in order to deliver exposure data as quickly as 5 days following dosing.
(Figure 1) We will work with our clients to provide PK parameters such as AUC and bioavailability,
(Figure 2) With bile duct cannulated rats housed in metabolism cages- plasma, bile, urine, and feces samples can be collected for a deeper dive into your drug candidates metabolic pathway,
(Figure 3) Our clients don’t have to wait on important DRF study data to inform their toxicology studies. We have extensive experience conducting PK confirmation and DRF studies.
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