Quantitation of Succinic Acid and Alpha-Ketoglutarate in Biological Samples on a High-Resolution Mass Spectrometer

Andrew Pinkham
Case Study

In a recent APA presentation led by Andrew Pinkham, we looked at a key analytical challenge — accurately quantifying small, highly hydrophilic organic acid biomarkers such as succinic acid and alpha-ketoglutarate.

By applying 4-BNMA derivatization with the SCIEX 7600 Zeno TOF platform, our team developed a reliable non-GLP method that delivers the accuracy and precision needed for confident biomarker quantitation.

Review highlights from the presentation and reach out should you want to further discuss how Meadowhawk can help you design fit-for-purpose bioanalytical solutions that adapt to the unique properties of different modalities.

Andrew Pinkham

Principal Scientist II, LCMS Bioanalysis

Andrew has nearly a decade of experience with development and execution of regulated and discovery bioanalytical LC-MS/MS assays within a CRO environment. He specializes in supporting bioanalysis of complex molecules by LC-MS including modalities such as proteins, antibodies, ADCs, and oligonucleotides. Andrew received his BS degree in Biochemistry from Rochester Institute of Technology and completed his PhD in Chemistry at The Ohio State University.